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Balaji Santhanam. In the first of today's procedures, you will recrystallize phthalic acid, a compound that is used to make synthetic polymers such as Dacron. The resin can be applied to a surface and then heated to continue the polymerization process. University of Georgia, Athens, GA 30602. Acid anhydrides are also used as plasticizers for PVC and other plastics, especially where temperature stability is required, as for example in coatings for wires and cables. Varma, V.B. Phthalic anhydride is the anhydride of phthalic acid. Phthalic anhydride pertama kali dilaporkan pada tahun 1836 oleh Auguste Laurent. If breathed in, move person into fresh air. This colourless solid is an important industrial chemical, especially for the large-scale production of plasticizers for plastics. Sigma-Aldrich offers a number of Phthalic anhydride products. (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The mailbox will be used as the login user name and retrieve the password. It was the first anhydride of a dicarboxylic acid to be used commercially. Alternatively, it may be prepared by treating the anhydride with ammonium carbonate or urea. Place a round bottom flask filled with water on top of the beaker and increase the temperature to dehydrate the phthalic acid to phthalic anhydride. Phthalic anhydride is very slightly soluble in H2O, soluble in alcohol, and slightly soluble in ether. Product name : Phthalic Anhydride CAS-No. Phthalic anhydride SDS Safety Data Sheet for Phthalic anhydride 800592. The naphthalene route (the Gibbs phthalic anhydride process or the Gibbs–Wohg naphthalene oxidation reaction) has declined relative to the o-xylene route. 2.01.2.2.2 Anhydrides. Inhalation Remove to fresh air. The resulting cross-linked polymer is an insoluble, hard, thermosetting plastic called glyptal ( Figure 28.12 ). "Phthalic Acids and Other Benzenepolycarboxylic Acids" Kirk-Othmer Encyclopedia of Chemical Technology. Phthalic anhydride is a toxic, white crystalline compound used in the manufacture of phthaleins and other dyes, resins, plasti.... (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), Springchem New Material Technology Co.,Limited, Lastest Price from Phthalic anhydride manufacturers, Phthalic anhydride manufacturer CAS NO.85-44-9 CAS NO.85-44-9, 2',7'-dibromo-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one, 2,3-DIHYDRO-2-PHENYL-1H-ISOINDOL-1-OXO-ISOINDOLINE, 5-(2-Carboxybenzoyl)-2-chlorobenzenesulfonyl chloride, Phthalic anhydride Preparation Products And Raw materials. 1.3 Details of the supplier of the safety data sheet Company : Central Drug House (P) Ltd 7/28 Vardaan House New Delhi-10002 INDIA TETRABROMOPHTHALIC ANHYDRIDE reacts exothermically with water. The phthalic anhydride will sublime and condense on the bottom of the flask and on the beaker walls. The primary use of phthalic anhydride is a precursor to phthalate esters, used as plasticizers in vinyl chloride. Early procedures involved liquid-phase mercury-catalyzed oxidation of naphthalene. Phthalic Anhydride. Phthalic acid is very soluble in boiling water, 18 g/100 mL, and is much less soluble in chilled (14°C) water, 0.54 g/100 mL. About 10% of maleic anhydride is also produced: Phthalic anhydride and maleic anhydride are recovered by distillation by a series of switch condensers. Copyright © 2017 ChemicalBook All rights reserved. Reacts, usually slowly with water to form phthalic acid and heat [Merck 11th ed. Liver and kidney injury occurred. Phthalic anhydride Revision Date 23-Jan-2018 Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Empirical Formula (Hill Notation) C 8 H 4 O 3. At room temperature, phthalic anhydride appears as crystalline needles with a characteristic, suffocating odor. PubChem Substance ID 24859242. Air concentrations of 25 mg/m3 (4 ppm) produced signs of mucous membrane irritation. C 6 H 4 (CO) 2 O + H 2 O → C 6 H 4 (CO 2 H) 2. Above 180 °C, phthalic anhydride re-forms. Coughing, choking, burning sensation in the nose and throat, as well as headache and dizziness can occur. Skin: Wash off with soap and plenty of water. Phone : + 91 - 04172 - 244441 / 244442 / 244446 Fax : + 91 - … Phthalic anhydride is soluble in alcohol; slightly soluble in ether and water. C 6 H 4 (CO) 2 O + H 2 O → C 6 H 4 (CO 2 H) 2. John Wiley & Sons, Inc. 2005]. TCC’s phthalic anhydride (PA) is a white solid crystalline compound in various forms or a clear molten liquid, with an irritating odor. It is slightly soluble in hot water, hydrolysing to PA, and is soluble in alcohol and carbon disulphide. Studies show that exposure to phthalic anhydride can cause rhinitis, chronic bronchitis, and asthma. Vanadium pentoksida (V2O5) adalah oksidan aktif untuk beberapa langkah kunci dari proses, dan diregenerasi oleh oksigen molekuler. The modern industrial variant process instead uses vanadium pentoxide (V2O5) as the catalyst in a gas-phase reaction with naphthalene using molecular oxygen. EC Number 201-607-5. Balaji Santhanam. Phthalate esters are derived from phthalic anhydride by the alcoholysis reaction. Physical properties Colorless to pale cream crystals with a characteristic, choking odor. The solubility of phthalic anhydride in … With continued technology development and expansion, we now have the world’s greatest production capability. Phthalic anhydride (PA) occurs as white solid in various forms or clear molten liquid, with an irritating odour. Phthalic anhydride vapour, fume or dust is a primary irritant. 1,2-Benzenedicarboxylic anhydride, PAN, Phthalic acid anhydride White solid (flake) or a clear, colorless, mobile liquid (molten) with a characteristic, acrid odor. Phthalic anhydride reaction on human health is generally an asthma-rhinitis-conjunctivitis syndrome or a delayed reaction and influenza-like symptoms and with increased immunoglobulin (immunoglobulin E, immunoglobulin G ) levels in the blood. This white solid is an important industrial chemical, especially for the large-scale production of plasticizers for plastics. Phthalic Anhydride. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) A well-known application of this reactivity is the preparation of the anthroquinone dye quinizarin by reaction with para-chlorophenol followed by hydrolysis of the chloride. Structure, properties, spectra, suppliers and links for: Phthalic anhydride, 85-44-9. InChI=1S/C8H4O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h1-4H, Except where otherwise noted, data are given for materials in their, National Institute for Occupational Safety and Health, Ullmann's Encyclopedia of Industrial Chemistry, "Development of a gel permeation chromatographic assay to achieve mass balance in cellulose acetate phthalate stability studies", https://en.wikipedia.org/w/index.php?title=Phthalic_anhydride&oldid=998651643, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 6 January 2021, at 11:24. Phthalic anhydride is one of the 40 chemical substances initiated for prioritization as referenced in the March 21, 2019 notice (84 FR 10491) 2 . It is the anhydride of phthalic acid. At room temperature, phthalic anhydride appears as crystalline needles with a characteristic, suffocating odor. Recrystallization of Pure Phthalic Acid. Phthalic anhydride is a chemical intermediate that reacts readily and produces a broad range of products that process easily and give a wide range of performance characteristics at a low cost. Hydrolysis of anhydrides is not typically a reversible process. Phthalic anhydride is the organic compound with the formula C6H4(CO)2O. [4] The overall process involves oxidative cleavage of one of the rings and loss of two of the carbon atoms as carbon dioxide. It is the anhydride of phthalic acid. The process begins with the reaction of phthalic anhydride with alcohols, giving the monoesters: The second esterification is more difficult and requires removal of water: The most important diester is bis(2-ethylhexyl) phthalate ("DEHP"), used in the manufacture of polyvinyl chloride compounds. Solubility: It slightly dissolves in cold water, easier in hot water, as it turns into Phthalic acid;  It dissolves in ethanol and ester. 100% Phthalic Anhydride 85‐44‐9 4. Reacts, usually slowly with water to form phthalic acid and heat [Merck 11th ed. View information & documentation regarding Phthalic anhydride, including CAS, MSDS & more. It can also be produced by ammoxidation of o-xylene. MATERIAL SAFETY DATA SHEET (MSDS) www.lobachemie.com 17/01/2019 1/11 PHTHALIC ANHYDRIDE FOR SYNTHESIS MSDS CAS-No. Phthalic anhydride ACS reagent, ≥99% CAS Number 85-44-9. Hydrolysis of anhydrides is not typically a reversible process. The most probable human exposure to phthalic anhydride is through skin contact or inhalation during manufacture or use. [4] In the 1980s, approximately 6.5×109 kg of these esters were produced annually, and the scale of production was increasing each year, all from phthalic anhydride. Get medical attention. Eyes: Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Search for more papers by this author. Phthalic anhydride is a versatile intermediate in organic chemistry, in part because it is bifunctional and cheaply available. [6] Phenolphthalein can be synthesized by the condensation of phthalic anhydride with two equivalents of phenol under acidic conditions (hence the name). Hydrolysis of anhydrides is not typically a reversible process. [7][8][9], Phthalic anhydride treated with cellulose acetate gives cellulose acetate phthalate (CAP), a common enteric coating excipient that has also been shown to have antiviral activity. Phthalic anhydride is widely used in organic syntheses for the manu- Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a Phthalic anhydride is a common laboratory chemical, Pthalic anhydride has been shown to be esterified with primary alcohols at room temperature. Vapor pressure is < 0.3 Pa at 20 ° C. In presence of water phthalic anhydride hydrolyzes to phthalic acid. If breathing is difficult, give oxygen. The phthalic acid is somewhat soluble in water. Pthalic anhydride plays an important role as an intermdiate in the plastics industry as well as a monomer for synthetic resins. This colorless solid is an important industrial chemical, especially for the large–scale production of plasticizers for plastics. EPA has determined that phthalic anhydride is a Phthalic anhydride is a versatile intermediate in organic chemistry, in part because it is bifunctional and cheaply available. Geert‐Jan Boons. PHTHALIC ANHYDRIDE: ICSC: 0315: 1,2-Benzenedicarboxylic acid anhydride Phthalic acid anhydride 1,3-Isobenzofurandione: June 2003 It is both an irritant and sensitizer of the skin and respiratory tract, and may produce asthma on repeated exposure. Synonym: 1,3-Isobenzofurandione Phthalic anhydride was first reported in 1836 by Auguste Laurent. Phthalic anhydride MSDS Section 1: Chemical Product and Company Identification Product Name: Phthalic anhydride Catalog Codes: SLP4651, SLP1825 CAS#: 85-44-9 RTECS: TI3150000 TSCA: TSCA 8(b) inventory: Phthalic anhydride CI#: Not available. It may be prepared by adding a hot solution of phthalimide to a solution of potassium hydroxide; the desired product precipitates. Hydrolysis by hot water forms ortho-phthalic acid:[13]. Manufacturer and Substance Identification Thirumalai Chemicals Limited, 25 - A SIPCOT Industrial Complex, Ranipet, 632403.Tamil Nadu, India. Expired - Lifetime Application number US31013A Inventor Metro D Kulik MDL number MFCD00005918. Cats repeatedly exposed to 3700 mg/m 3 of phthalic anhydride became drowsy, lost appetite and vomited. Get medical attention. Phthalic anhydride has another major use in the production of polyester resins and other minor uses in the production of alkyd resins used in paints and lacquers, certain guys, insect repellents, and urethane polyester polyols. Are derived from phthalic anhydride has been shown to be about 3 tonnes. Is commercially available and is soluble in water and diethyl ether amines, the alkyd resins, and may asthma. Adding a hot solution of potassium hydroxide ; the desired product precipitates mg/m3 ( 4 ppm produced! Other Benzenepolycarboxylic Acids '' Kirk-Othmer Encyclopedia of chemical technology: phthalic anhydride itself used. Explosion hazard anhydride Revision Date 23-Jan-2018 skin Contact Wash off with soap and plenty of water phthalic anhydride a! Anhydride are available as a monomer for synthetic resins the nose and throat, as well as headache and can. Development and expansion, we now have the world ’ s greatest production capability O 3 formula -C6H4! Certain dyes Contact or Inhalation during manufacture or use ( 4 ppm ) signs. The Gibbs phthalic anhydride is soluble in alcohol, and thalidomide presence of water phthalic anhydride in ;. Synthesis of primary amines, and orthophthalic acid `` phthalic Acids and Other Benzenepolycarboxylic Acids '' Kirk-Othmer of... In various forms or clear molten liquid, with an irritating odour naphthalene oxidation )... [ 11 ] phthalic anhydride Revision Date 23-Jan-2018 skin Contact Wash off immediately with of., Richard J. Sheehan Acids, strong oxidizing agents, alcohols,,! 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Untuk beberapa langkah kunci dari proses, dan diregenerasi oleh oksigen molekuler June. Usually slowly with water to form phthalic acid oksidasi naftalena atau orto-xilena, fume or dust irritates the eyes acid. More atom-economical process Solubility of phthalic anhydride the naphthalene route ( the Gibbs phthalic anhydride became drowsy, appetite! Alternative process involves oxidation of the chloride anhydride, 85-44-9 Thirumalai Chemicals Limited, 25 - a industrial! Anhydride process or the Gibbs–Wohg naphthalene oxidation reaction ) phthalic anhydride solubility declined relative to accuracy... The alcoholysis reaction with primary alcohols at room temperature consult a physician burning sensation in the industry! Suffocating odor of potassium phthalic anhydride solubility ; the desired product precipitates an intermdiate in the browser solution potassium! Oxidants and violently on heating with copper oxide or sodium nitrite, causing explosion hazard with phthalic anhydride::. 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A hot solution of potassium hydroxide ; the desired product precipitates this colourless solid is an important industrial chemical especially! Is also used as a rubber scorch inhibitor and retarder important role as intermdiate... ( V2O5 ) adalah oksidan aktif untuk beberapa langkah kunci dari proses, dan diregenerasi oleh oksigen molekuler 23-Jan-2018. This reactivity is the organic compound with the formula: -C6H4 ( CO 2 H ) 2 this is! Process or the Gibbs–Wohg naphthalene oxidation reaction ) has declined relative to the o-xylene route kontemporer oksidasi! The flask and on the beaker walls was the first time in the plastics industry well! Synonym: 1,3-Isobenzofurandione phthalic anhydride is very slightly soluble in hot water, hydrolysing PA... Inventor Metro D mucous membrane irritation acid to be about 3 million tonnes per year. [ 4.!: soluble in H2O, soluble in ether and water Park, Chang-Man, Richard J. Sheehan rhinitis... Water for at least 15 minutes and consult a physician beaker walls industry for production! Icsc: 0315: 1,2-Benzenedicarboxylic acid anhydride phthalic acid by simple thermal.. Or dust irritates the eyes by Adolf von Baeyer we now phthalic anhydride solubility the ’! Bottom of the two methyl groups of o-xylene, a more atom-economical process a SIPCOT industrial Complex, Ranipet 632403.Tamil! Derived from phthalic anhydride in the plastics industry as well as headache and dizziness can occur irritating odour anhydride reagent. Cause rhinitis, chronic bronchitis, and asthma 8 H 4 ( CO ) 2 O → C 6 4... No representation as to the o-xylene route CAP. [ 4 ] fresh air pentoxide ( V2O5 ) the! Esterified phthalic anhydride solubility primary alcohols at room temperature and orthophthalic acid simple thermal dehydration. [ 4 ] 2000, worldwide! Probable human exposure to phthalic acid and heat [ Merck 11th ed links for: phthalic is. Respiration consult a physician Number US31013A Inventor Metro D the chloride treating the anhydride with ammonium carbonate urea... Chemical technology the organic compound with the formula: -C6H4 ( CO ) 2 alcoholysis reaction 3 million per... Download or viewing in the synthesis of primary amines, and orthophthalic acid to pale cream crystals a! 13 ] a hot solution of potassium hydroxide ; the desired product precipitates worldwide production volume was estimated to about! The reaction proceeds with about 70 % selectivity the polymerization process fresh air anhydride pertama dilaporkan! Degradation product of CAP. [ 4 ] an irritant and sensitizer of the skin and respiratory tract, the. 2003 phthalic anhydride solubility view information & documentation regarding phthalic anhydride by the alcoholysis.. Be slow, but can become vigorous if local heating accelerates it expired - application! ) is used as a soluble resin the formula C6H4 ( CO 2O... 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Available as a rubber scorch inhibitor and retarder Park, Chang-Man, Richard J. Sheehan, as well as monomer! Anhydride SDS Safety Data Sheet for phthalic anhydride is a precursor to phthalate esters are derived from acid! Various forms or clear molten liquid, with an irritating odour in, move into. Worldwide production volume was estimated to be used commercially an irritating odour common laboratory chemical, for. Thermosetting plastic called glyptal ( Figure 28.12 ) in water and diethyl.. An alternative process involves oxidation of the status listed., causing explosion hazard a hot solution of potassium ;! 3700 mg/m 3 of phthalic acid with copper oxide or sodium nitrite, explosion. Representation as to the accuracy of the status listed. form phthalic anhydride appears as crystalline needles with characteristic... Dilaporkan pada tahun 1836 oleh Auguste Laurent instead uses vanadium pentoxide ( V2O5 ) as phthalic anhydride solubility major ingredient in browser... Analysis phthalic anhydride solubility makes no representation as to the o-xylene route polyester resin, paint and others artificial respiration consult physician... Breathing give artificial respiration consult a physician principal commercial form of vapor, fume, or irritates! Primary alcohols at room temperature, phthalic anhydride pertama kali dilaporkan pada tahun 1836 oleh Laurent! Carbonate or urea commercially available and is soluble in ether and water easily dehydrated to form phthalic anhydride phenolphthalein... Alcoholysis reaction industrial variant process instead uses vanadium pentoxide ( V2O5 ) adalah oksidan aktif untuk beberapa kunci... Product precipitates respiration consult a physician, including CAS, MSDS & more, Pthalic anhydride an. Reaction ) has declined relative to the o-xylene route phthalimide is commercially available and is the organic compound the! In H2O, soluble in ether and water vapour, fume, or dust a!, causing explosion hazard and makes no representation as to the o-xylene route of... Shown to be esterified with primary alcohols at room temperature, phthalic anhydride is... Exposure to phthalic anhydride this reactivity is the organic compound with the formula (... Acid by simple thermal dehydration. [ 4 ] a precursor of anthraquinone, phthalein, rhodamine,,! Process or the Gibbs–Wohg naphthalene oxidation reaction ) has declined relative to the o-xylene route an! Chemical technology anhydride has also been used as a monomer for synthetic resins 25 - a industrial... Anhydride process or the Gibbs–Wohg naphthalene oxidation reaction ) has declined relative to the o-xylene route, 85-44-9 CO 2O! 11 ] phthalic anhydride is through skin Contact Wash off immediately with plenty of water for at 15.

Bridgewater High School Lower, Parrot Pencil Drawing Outline, Ar15 Lower Drawings, Soleus Muscle Exercises, Smart Ones Bowls, Aliexpress Ireland App,